By Swami Darmanand ji
RESEARCH STUDY OF REVERSAL OF CORONARY HEART DISEASE
THROUGH PREKSHA MEDITATION WITH REFRENCE TO -
CORONARY ATHEROSCLEROTIC REVERSAL POTENTIAL OF YOGA LIFE STYLE INTERVENTION
S.C.Manchanda MD. R. Narang MD, K.S. Reddy MD, U Sachdeva MD, D. Prabhakaran MD,
S. Dharmananda BA, M. Rajani MD, R.L. Bijalani MD.
Background: It is not clear if lifestyle modification has any role in control of
symptoms, progression of coronary lesions and prognosis in patients with
advanced obstructive coronary artery disease.
Methods: In the prospective, randomised, controlled trial, 42 men with
angiographically proven coronary obstructive disease were randomized to control
(n=21) and yoga intervention group (n=21) and were followed for 1 year. The yoga
lifestyle programme was a user friendly program consisting of strict control of
risk factors, diet control (15% calories from fat, mostly mono-and
polyunsaturated 65% from carbohydrate, mostly complex, 20% from proteins, high
fiber (> 50 g/day) and antioxidants), moderate aerobic physical exercise, health
rejuvenating exercises, breathing and relaxation exercises, stress management,
meditation and reflection on moral values. The patients were taught various
yogic exercises at yoga centre which they later practiced everyday at home. The
control group was managed by conventional methods, i.e. risk factors control and
AHA step I diet.
Results: At the end of 1 year, the yoga groups showed significant improvement in
number of anginal episodes, improved exercise capacity and decrease in body
weight, and total and LDL cholesterol and serum triglyceride levels as compared
to controls. Coronary angiography repeated at 1 year showed that significantly
more lesions regressed (20% versus 2% and less lesion progressed (5% versus 37%)
in the yoga group (chi-square = 24.9; P<0.0001). Revascularisation procedures
(coronary angioplasty or bypass surgery) were much less frequent in the yoga
group (1 versus 8 patients; relative risk 5.45; P=0.01) The compliance of the
total programme was excellent and no side effects were observed.
Conclusions: Yoga lifestyle intervention is beneficial in improving the symptoms
and exercise capacity, lowering weight and serum lipid levels. It also retards
the progression of coronary atherosclerosis in-patients with severe coronary
artery diseases and reduces revasularisation procedures.
A number of studies have documented that a change in lifestyle (chiefly
consisting of dietary modifications, physical exercises and stress relaxation
techniques) results in reduction of cardiac events in patients with coronary
artery disease (CAD). However, there is a paucity of studies to determine
whether lifestyle modification can result in regression of the coronary
atherosclerotic plaques. Ornish et al observed a regression of coronary
aterosclerotic obstruction by strict lifestyle intervention. However the
coronary stenoses were mild (40% and 43% diameter stenosis in treatment and
control groups. Respectively) and the diet prescribed in their study was also
very stringent. With only 5mg of cholesterol allowed per day. It is likely that
such strict control of diet may not be practical for most patients.
The present study was designed to assess the effects of strict but "user
friendly" intervention using yoga lifestyle methods (with strict control of risk
factors) on the angioraphic severity of atherosclerotic obstructions in patients
with advanced CAD (>70% luminal diameter stenosis in at least 1 vessel). The
effects on symptoms, exercise capacity serum lipids and cardiovascular events
were also analyzed.
Aims & objectives
The objective of this study was to determine whether a user-friendly yogic
lifestyle intervention program (including yogic exercises, dietary management,
moderate aerobic exercise and stress management) with control of other risk
factors can reverse the atherosclerotic obstructions in patients known to have
coronary artery disease.
Material and Methods
Forty-two male patients (mean age 51.0 + 9.5 range 32-72 years) with
angiographically proven CAD were included in this prospective, randomized,
controlled trial. At baseline detailed clinical assessment, serum lipid profile,
treadmill exercise testing using modified Bruce protocol and coronary
arteriography were performed.
Patients in the control group (n=21) were managed on conventional medical
therapy (with control of risk factors, AHA step 1 diet, moderate aerobic
exertion), while those in the yoga group (n=21) were advised strict lifestyle
modifications and yogic exercises as detailed below. The medications for angina
were continued. No patient was receiving lipid-lowering drugs. The patients were
followed for 1 year with regular assessments. At the end of 1 year, the patients
again underwent detailed clinical assessment, serum lipid profile, treadmill
exercise test and repeat coronary arteriography. Coronary arteriography was
analyzed quantitatively using the caliper method. All arteriograms were analyzed
by two independent blinded observers. For coronary angiography the effect on
individual lesions was compared in the 2 groups. Ethical clearance was obtained
from the institutional ethics committee and all patients gave informed consent
to take part in the study.
The baseline characteristics of the patient population are detailed in table 1.
Most patients were in NYHA functional class II(52% patients) or class III (41%
patients). The patients in both groups had elevated mean total and low-density
lipoprotein cholesterol. The study was conducted before the results of major
trials of statins in coronary artery disease were published and none of the
patients were on lipid lowering therapy. All patients had at least 1 mm ST
segment depression during exercise testing. Coronary arteriography showed
majority (81%) of patients to be have triple vessel disease.
Yoga lifestyle intervention program
After inclusion in the yoga group, patients, alongwith their spouses, spent
4 days at a yoga residential centre, where they underwent training in various
yogic lifestyle techniques. The yogic lifestyle intervention program consisted
� Yogic lifestyle methods
1. Health rejuvenating exercises: a set of movements for improving the general
tone of the body and to improve coordination.
2. Relaxation exercise (Kayotsarg): a method of complete relaxation to prepare
the body and mind for meditation.
3. Breathing exercises (Pranayama)
4. Yogic postures for stretch relaxation (Asanas)
5. Preksha meditation (Preksha means seeing deeply within)
6. Reflection on moral values (Anuvrat and Anupreksha)
� Stress management (relaxation, breathing exercises and Preksha meditation)
� Dietary control.
� Moderate aerobic exercises.
Patients visited the yoga centre every fortnight for monitoring and evaluation.
The compliance as reported by patients themselves and by spouse, was recorded.
In addition, the patients were followed every month in cardiac clinic of the
hospital for clinical examination and investigations.
Patient were advised take a low fat (mostly poly-or monounsaturated,
providing15%of calories), low cholesterol (<50 mg/d), high carbohydrate (mostly
complex, providing 65% of calories) diet. Patients were also encouraged to have
high soluble fiber diets (>50gm/d) consisting of vegetable and fruits, oat bran,
soybeans, gram and other beans, They were also prescribed 15gm psyllium husk
(almost entirely fiber) daily. In addition, the diet advised was rich in
antioxidants (carrots for beta-carotene, fruits, for vitamin C, nuts like
almonds and walnuts for vitamin E and flavonoids from onions, coloured fruits
and vegetables). Illustrative recipes and menus with known nutritional values
were provided to avoid monotony.
The compliance of patients was assessed in a quantitative manner using a
standard questionnaire and the score could range from 0 to 100.
All data are presented a mean � SD unless stated otherwise. The results at the
end of 1year were compared with those at the baseline. The changes in the yoga
group were compared with those in the control group. The P values were
calculated using student's t-test for paired data. Chi-square analysis using
Yate's correction was performed wherever appropriate.
Both groups were similar at baseline with respect to mean age, weight, serum
lipid profile, and mean lesion severity (Table1). However, patients in yoga
group had significantly more.
TABLE I. Baseline characteristic of yoga and control groups
TABLE II. Parameters at baseline and at 1 year in
the yoga and control groups.
Patients in the yoga group showed an improvement in the NYHA functional class
while patients in the control group showed an overall worsening (p<0.0001). The
number of episodes of angina per week reduced by 73% in the yoga group. While
they increased by 47% in the control group (Table II).
The body weight showed a small but statistically significant decrease (7% P=
0.002) in the yoga group while the control group which did not show any
significant alteration. The lipid profile showed significant reduction in the
level of total and LDL cholesterol as well as triglycerides in the yoga group
(about 20% reduction in each of these table II) while these parameters showed no
significant change in the control group. Though there these was no beneficial
effect on the HDL levels. The atherogenic ratio (total/HDL cholesterol) reduced
significantly in the yoga group.
There was an improvement in the exercise duration and a reduction in the degree
of ST segment depression occurring during the stress test in the yoga group. On
the other hand patients in the control group showed a reduction in the exercise
duration and an increase in the ST segment depression occurring during exercise
(P=0.0007 and 0.0001 respectively).
Coronary arteriography was repeated at 1 year in all patients. A total of 120
lesions were analyzed (61 in the yoga group and 59 in the control group) At
baseline there was no significant difference in the mean severity of lesions in
the two groups (62.4% vs 59.7% diameter stenosis). At 1 year there was
progression of coronary stenosis in the control group (mean worsening of 9+13%
diameter stenosis) whereas the yoga group showed no significant change. This
difference was highly significant (P< 0.0001).
The change in the lesion severity was classified into regression ( 10% absolute
reduction in diameter stenosis) no significant change (< 10% change in diameter
stenosis) or progression (> 10% absolute increase in diameter stenosis) In the
yoga group, 3 lesion showed progression 46 lesion showed no change while 12
lesion showed regression. In the control group 22 lesions showed progression 36
showed no change while 1 showed regression (Fig.1). This difference was highly
significant (chi-square 24.5. P< 0.0001).
Coronary artery bypass grafting (CABG) and percutaneous transluminal coronary
angioplasty (PTCA) were markedly reduced in the yoga group as compared to
controls. Only one patient in the yoga group needed revascularisation (PTCA) as
against 8 in the control group (2 PTCA and 6 CABG) (relative risk 5.45: P=0.01).
There are number of reports of a favourable effect of risk factor modification
in patients with coronary artery disease (secondary prophylaxis) Ornish et al
(1983) reported the short-term effects of stress management and dietary changes
in patients with coronary artery diseases. In this study of 46 patients (23 of
whom received this intervention), there was 44% mean increase exercise duration,
55% mean increase in total work performed and improved regional wall motion
during peak exercise. These changes occurred at a mean of only 24 days of
intervention. There was a remarkable 91% reduction in the frequency of anginal
episodes. The mean reduction in plasma cholesterol levels was 21%.
Subsequently in the lifestyle Heart Trial ornishet al (1990) studied the effect
of comprehensive lifestyle changes (low fat vegetarian diet, stress management
training moderate exercise and stopping smoking) on the severity of CAD
determined by quantitative coronary arteriography. After 1 year of follow up
analysis of 195 lesions in 48 patients (28 in the active group) shoed that the
average diameter stenosis regressed in the active group (from 40+17% to 37.8
+16.5%) while it progressed in the control group (from 42.1�15.5% to 46.1�18.5)
overall 82% of active group patients had an average change towards regression.
It was concluded that comprehensive lifestyle changes can produce regression of
obstructive coronary artery disease after only one year, without the use of
lipid -lowering agents. Gould et al (1992) from the same group subsequently
showed that complex shape changes and stenoses moudling characteristics occur
over a period of time. Such changes result in an overall regression of the
severity of lesions with improved stenosis flow reserve with intensive lifestyle
modifications, while these changes result in overall progression of stenosis
severity and worsening flow reserve in the control group.
In a recent study. Gould al (1995) showed that such risk factor modification
also results in a decrease in the size and severity perfusion abnormalities on
rest dipyridamole position emission topography (PET) reflecting an improvement
in the integrated flow capacity of the entire coronary arterial circulation. The
size and severity of abnormalities increased in the control group over 5 year
Studies from Heidelbey have also demonstrated the benefical effects of
comperehensive lifestyle changes (including diet and physical exercise) on the
coronary anatomy in-patients with CAD. Lipid lowering agent were not prescribed.
After 1 year, the intervention group showed progression in 23% and regression in
32% patients, compared with 48% and 17% respectively in the control group
(P<0.05). The benefit persisted at 6 years of follow-up (P<. 0001). A
multivariate analysis identified only physical work capacity as independently
contributing to angiographic changes.
Effects of comprehensive program of risk reduction involving both changes in
lifestyle and medication were evaluated in the Stanford Coronary
Risk Intervention Project (SCRIP) 15. Again the risk reduction group showed a
47% reduced progression of coronary artery segments as compared with the usual
care group (P<. 02).
The results of our study are consistent with those of the above mentioned
studies. Yoga lifestyle intervention was found to have several beneficial effect
in-patients with coronary artery disease, even when the disease was advanced. It
markedly improved symptoms of angina and the exercise capacity of these
individuals. It also reduced the body weight & favorably attired the lipid
level. It also reduced total and low density lipid cholesterol as well as serum
triglyceride levels, though the HDL cholesterol was not significantly affected
Coronary angiography showed retardation of progression of the disease as well as
regression of significantly more lesions as compared to the control treatment.
The revasculanzation procedures were significantly less in the yoga lifestyle
group, though the numbers were small. This may be related to " stabilization" of
the atheromatous plaques similar to that thought to occur following statin
The main advantage of our program was that it was much more "user friendly" than
the interventions used in previous studies such as those by Ornish and Gould.
The dietary modification in our study was also more liberal as 15% of energy
from fats and 50 mg of cholesterol per day were allowed as compared with 10%
energy from fats and only 5 mg of cholesterol per day in the study by Ornish et
al. The patients included in our study also had significantly more severe
disease (81% had triple vessel disease). Many of these patients had earlier
declined to undergo revascularisation procedures. Moreover ours is perhaps the
only study which assessed the effects of yoga lifestyle intervention on the
angiographic severity in-patients with advanced CAD.
Limitations of the study
We recognize several limitation of this study
1. Relatively small number of patients have been studied. Though the result are
encouraging the need to be replicated in larger number of patients.
2. The patients in the yoga group had more rigorous follow-up though the control
group was also followed regularly.
3. By nature of the interventions involved the study could not be blinded and
hence a placebo effect of yoga intervention cannot be excluded. However the
coronary angiograms were interpreted by blinded observers.
4. The compliance of diet and yoga exercises was monitored from the reports of
patients themselves and was not directly observed by the investigators. However
the spouses of the patients in yoga were also involved and they also monitored
te compliance of patients.
5. The luminal diameter stenosis was measured quantitatively by caliper method
and not by automatic edge detection techniques using dedicated software systems.
However, the caliper method has been used widely in angiographic studies.
6. The differential effects of yogic exercise dietary control and aerobic
exercises were not assessed. We considered yoga lifestyle modification program
as a composite intervention incorporating all the above mentioned components.
However despite above limitations, outcome variables in the two groups are
significantly different and are likely to be clinically important.
The study shows that yoga lifestyle intervention program is possible to carry
out in-patients with advanced coronary artery disease with a high degree of
compliance. It has favorable effect on angina, body weight, lipid levels,
exercise stress testing with retardation of progression of coronary obstruction
as compared with control group. Yoga lifestyle appears to stabilize the
atherosclerotic plaques thus decreasing the need for revascularization
procedures. Hence, yoga lifestyle is a feasible and cost-effective intervention
in-patients with advanced coronary artery disease.
We are grateful to Swami Dharmanada for imparting the yoga training to the
participants of this study and for supervising their progress. The study was
supported in part by a grant from the Council of Yoga and Naturopathy, Ministry
of Health, Government of India.
Outline of yogic exercises that formed part of yoga lifestyle modification
A. Health Rejuvenating Exercise: These exercises are aimed mainly at improving
the general tone and flexibility of various parts of body. These were also
performed during warming up and to prepare for the next step, i.e. the asanas.
B. Asanas: These are the yogic postures and exercises mainly aimed at stretch
relaxation. A number of asanas were taught including Surya namaskar, Tadasana,
padshasta asana, Vajrasana, Shasank asana, ardha-matsyendrasana,
Paschimottantasana, Bhujangasana, Dhanush ban asana, Shalabhasana, Uttanpadasana,
Merudandasana, Pawan Muktasana, Sarwangasana, Matsyasana, Ardhamatsyasana and
Pranayam.The detaisl of these asanas can be found in any book on yogic exercise.
C. Kayotsarga: A method of complete relaxation and preparation of body and mind
for meditation. The literal meaning of Kayotsarga is to drop the body. In
practice it is the conscious suspension of all movements of the body. As a
result the muscle relax and the person becomes as restful as in sleep.
D. Preksha Dhyan: Preksha means perception and Dhyan means concentration.
Preksha Dhyan is performed in the sitting position and person first relaxes the
body using Kayotsarga. He then concentrates on the breath and gradually and
consciously reduces the rate of breathing from 15-17/ minute to 10-12/ minute.
With practice, the rate may be reduced even to 4-6/ minute. By concentrating on
the breath, the mental activity is controlled and the mind is prevented from
E. Anuvrat and Anupreksha: Anupreksha means contemplation or reflection or
thoughtful consideration. Anuvrat is concerned with moral values, which would
include consideration for others, unity of mankind, communal harmony,
non-violence, limitation of acquisition and consumption, integrity in behavior
and purity of means.
1. Superko HR, Wood PD,Haskell WL. Coronary heart disease and risk factor
modification is there a threshold? Am J Med 1985: 78 826-38.
2. Raichlen JS. Healy B. Achuff SC. Pearson TA Importance of risk factors in the
angriograohic progession of coronary artery disease. Am J cardiol 19220.127.116.11
3. Glueck CJ. Role of risk factor management in progression and regression of
coronary and femoral artery atherosclerosis. Am J Cardiol 1986.57 35G.
4. Ornish D. Schewitz LW. Doody RS.kesten D et al effects of stress management
training and dietary changes in teating schaemic heart disease JAMA 1983 249 54
5. Ornish D. Brown SE. Scherwiz LW. Buillings JH et al can lifestyle chagnes
reverse coronary heart disease? The lifestyle Heart Trial. Lancet
7. Gould KL. Ornish D. Kirkeerde R. Brown S. stuart Y et al Improved sterosis
qeometry by quantitatively coronary arteriography after vigorous risk factor
modification Am. J. Cardel 1992.69.845-53.
8. Gould KL. Ornish D. Scherwitz L. Brown. S. et al changes in myocardial
perfusion abnormatities by positron emission tomography after long term, intense
risk factor modification JAMA. 1995.274 894 901.
9. Schuler G. Hambrecht R. Schliert. G. Niebauer J. Hauet K. Neumann J. et
alRegular physical exercise and low -fat diet. Effects of progression of
coronary artery disease Circulation 1992;86(1):1-11.
10. Niebauer J, llabrecht R, Velich T, llauer K, Marburger C, Kalbaerer B, et at
Attenuated progression of coronary artery disease after 6 years of multifactonal
risk intervention role of physical exercise Circulation 1997;96(8):2534-2541.
11. Niebauer J, . Hambrecht R, Velich T, Marburger C, et al Predictive value of
lipid profile for salutary coronary angiographic changes in patients on a
low-fat diet and physical exercise program Am J Cardiol 1996;78 163-167.
12. Niebauer J, . Hambrecht R, Marburger C, et al impact of intensive physical
exercise and low-fat diet on collateral vessel formation in stable
anginapectoris and angiographically confirmed coronary artery disease. Am J
13. Niebauer J, Hambrecht R, Schuler G, Marburger C, et al Five years of
physical exercise and low-fat diet : effects on progression of coronary artery
disease. J Cardiolpul Rehabul 1995; 15 47-64.
14. Hambrecht R, Niebauer J, Marburger C, et al Various intensities of leisure
time physical activity in patients with coronary artery disease effects on
cardiorespiratory fitness and progression of coronary atherosclerotic lesions.
Jam Coll Cardiol1993;22 468-477.
15. Schlude G. Hambrecht R. Schherf. G. et al Myocardial perfusion and
regression of coronary artery disease in aptients on a regmen of intensive
physical exercise and low fat diet J Am coll Cardiet 1992.1934-42.
16. Haskell WL. Alderman HL. Fat JM. Maron DJ. Macley SD. Supeto HR. Williams
Pt. Et.al effect of intensive multiple risk factor reduction on coronary
atheroscleroses and clinical cardio in men and woman with coronary artery
disease. The Stanford Coronary Risk Intervention project (SCRIP) Circulation
1994. 89.893) 975-990.
17. De Feyter PJ. Vos J. Dkeckers JW. Progression and regression of the
atherosclerotic plaque. Eur But Heart J 1995, Jun 16 (sippt 1) 26-30.
18. Shah PK New insights into the pathogenesis and prevention of acute coronary
syndromes AM. J. Cardiol 1997 Jun 26, 79 (12B) 17-23.
19. Fuster V. Human lesion studies Ann N Y Acad Ser 1997 Apr. 15 811 207-224.
20. Bjelajac A Goo AK Weart CW Prevention and regression of atherosclerosis
effects of HMG Coa reductase inhibitors Ann Pharmacother 1996 Nov. 30 (11)
21. Ganz P. Creager MA Fang JC, Mcconnel Mv. Lee RT, Libby P. Selwyn AP.
Pathogenic mechanisms of atherosclerosis effects of lipid lowering on the
biology of atherosclerosis. AM J Med 1996 Oct 8, 101(4A) 4A 1OS-4A 16S.
22. Stark RM Feview of the major intervention trials of lowering coronary artery
diseases risk through cholestrol reduction. Am J Cardiol 1996 Sep 26.78 (6A)
23. Shah PK. Pathophysiology of palgue repture and the concept of palgue
stabilization. Caardiol Clin 1996 Feb. 14 (1): 17-29.
24. Mahar VM Coronary atherosclerosis stabilization: an achievable goal.
Atherosclerosis 1995 Dec: 118 Suppt. S91-S101.
25. Mancim GB Mechanisms underlying reduction of clinical events in lipid
lowering trials. Can J Cardiol 1995 May: 11 Suppl. C: 15C-17C.
26. Okumura K, Yasue H, Hono Y, Takaoka K et al. Multivessel coronary spasm in
patients with variant angina: a study with intracoronary injection of
acetylcholine. Circulation 1988: 77: 535-42.
27. Coyne EP. Belvedere DA. Streek PRV Et al. Thallium-201 scintigraphy after
intravenous infusion of adenosine compared with exercise thallium testing in the
diagnosis of coronary artery diesease. J Am Coll cardiol 1991. 17 1289-94.
28. Hindohara T, Rowe MH, Robertson GC, Selmon et al. Effect on lesion
characteristics on outcoje of directional coronary atherectomy. J Am Coll Cariol
Jaul S Lilly DR. Gascho JA, Watson DD et al. Prognostic utility of the exercise
thallium 201 test in ambulatory patients with vhest pain: comparision with
cariac catheterization. Circulation 1988: 77 745-758.